肠道菌群的改变是酒精性脂肪肝的主要病因之

酒精性肝炎AH包含从亚临床炎症到急性肝衰竭的疾病谱。①酒精性肝病ALD中AH导致纤维化的风险最高，在40%病例中导致肝硬化；②住院患者一月死亡率高达40–50%；③AH患者在疾病严重性和病因方面是一个异质群体；③这种多样性的临床表现可能由多种因素造成，包括免疫和肠道菌群。

Title:Alteredintestinalmicrobiotaasamajordrivingforceinalcoholicsteatohepatitis

Abstract：Alcoholichepatitis(AH)coversaspectrumofdiseaseseveritiesfromsubclinicalliverinflammationtoacuteliverfailure.Amongthehistologicalfeaturesofalcoholicliverdisease(ALD),AHisassociatedwiththehighestriskoffibrosisprogres-sion,leadingtodevelopmentofcirrhosisin40%ofcases.PatientshospitalisedforsevereformsofAHshow1-monthmortalityratesof40–50%.PatientswithAHformaheterogeneouspopulation,inseverity,andprobablyindiseasepathogenesis.Thisdiverseclinicalpicturemightbecausedbyvariousfactorsincludinghostfactors,immunityandasrecentlysuggested,intestinalmicrobiota(IM).

AllAuthors:TilgH,MathurinP

FirstAuthors:HerbertTilg

Correspondence:HerbertTilg，PhilippeMathurin

DOI:10./gutjnl--